Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms.

ABSTRACT:

Background and aims

Determine the effect of AMPK activation and inhibition on the development of AAA (abdominal aortic aneurysm).

Methods

AAA was induced in ApoE^-/- mice by Ang II (Angiotensin II)-infusion. AICAR (5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside) was used as AMPK activator and Compound C was used as AMPK inhibitor. We further investigate the effect of metformin, a widely used anti-diabetic drug which could activate AMPK signal pathway, on the pathogenesis of aneurysm.

Results

Phospho-AMPK level was significantly decreased in AAA tissue compared with control aortas. AICAR significantly reduced the incidence, severity and mortality of aneurysm in the Ang II-infusion model. AICAR also alleviated macrophage infiltration and neovascula

SUBMITTER: Yang L 

PROVIDER: S-EPMC5696225 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature