Tumoral PD-L1 expression defines a subgroup of poor-prognosis vulvar carcinomas with non-viral etiology.

ABSTRACT: Vulvar cancer is rare but incidence rates are increasing due to an aging population and higher frequencies of young women being affected. In locally advanced, metastatic or recurrent disease prognosis is poor and new treatment modalities are needed. Immune checkpoint blockade of the PD-1/PD-L1 pathway is one of the most important advancements in cancer therapy in the last years. The clinical relevance of PD-L1 expression in vulvar cancer, however, has not been studied so far. We determined PD-L1 expression, numbers of CD3⁺ T cells, CD20⁺ B cells, CD68⁺ monocytes/macrophages, Foxp3⁺ regulatory T cells and CD163⁺ tumor-associated macrophages by immunohistochemistry in 103 patients. Correlation analysis with clinicopathological parameters

SUBMITTER: Hecking T 

PROVIDER: S-EPMC5696230 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature