Celastrol induces apoptosis in hepatocellular carcinoma cells via targeting ER-stress/UPR.

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most serious and deadly diseases worldwide with limited options for effective treatment. Biomarker-based active compound targeting therapy may shed some light on novel drugs for HCC. The endoplasmic reticulum (ER) stress and unfolded protein response (UPR) play important roles in the regulation of cell fate and have become novel signaling targets for the development of anticancer drugs. Celastrol, a triterpene from traditional Chinese medicine, has been reported to possess anti-tumor effects on various cancers. We, along with several other research groups, have recently reported that UPR was induced by celastrol in several different cancers, including hepatocellular carcinoma. However, UPR status in HCC still remains unclear. The role of ER stre

SUBMITTER: Ren B 

PROVIDER: S-EPMC5696242 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature