Diagnostic performance enhancement of pancreatic cancer using proteomic multimarker panel.

ABSTRACT: Due to its high mortality rate and asymptomatic nature, early detection rates of pancreatic ductal adenocarcinoma (PDAC) remain poor. We measured 1000 biomarker candidates in 134 clinical plasma samples by multiple reaction monitoring-mass spectrometry (MRM-MS). Differentially abundant proteins were assembled into a multimarker panel from a training set (n=684) and validated in independent set (n=318) from five centers. The level of panel proteins was also confirmed by immunoassays. The panel including leucine-rich alpha-2 glycoprotein (LRG1), transthyretin (TTR), and CA19-9 had a sensitivity of 82.5% and a specificity of 92.1%. The triple-marker panel exceeded the diagnostic performance of CA19-9 by more than 10% (AUC_CA19-9 = 0.826, AUC_panel= 0.931, P < 0.01) in all

SUBMITTER: Park J 

PROVIDER: S-EPMC5696248 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature