Association of Ezrin expression with the progression and prognosis of gastrointestinal cancer: a meta-analysis.

ABSTRACT:

Background

Ezrin, a cytoskeletal protein, is involved in cell adhesion. Several studies have been performed to explore the association between Ezrin and gastrointestinal cancers, but the results are inconclusive. This meta-analysis aims to assess the prognostic value of Ezrin.

Materials and methods/findings

PubMed and EMBASE were searched. Pooled hazard ratio (HR), odds ratio (OR) and 95% confidence intervals (CI) were utilized to evaluate the association between Ezrin expression and various clinical parameters. 2701 patients from 19 studies were included in the meta-analysis. For gastric cancer, Ezrin expression was associated with tumor grade (OR 2.32, 95% CI 1.53-3.52), TNM stage (OR 4.69, 95% CI 1.38-15.89), lymph node involvement (OR 3.96, 95% CI 1.47-10.70) and overall

SUBMITTER: Liang F 

PROVIDER: S-EPMC5696254 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature