Ontology highlight
ABSTRACT:
SUBMITTER: Fusella F
PROVIDER: S-EPMC5696377 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171121 1
NF-κB is a transcription factor involved in the regulation of multiple physiological and pathological cellular processes, including inflammation, cell survival, proliferation, and cancer cell metastasis. NF-κB is frequently hyperactivated in several cancers, including triple-negative breast cancer. Here we show that NF-κB activation in breast cancer cells depends on the presence of the CHORDC1 gene product Morgana, a previously unknown component of the IKK complex and essential for IκBα substrat ...[more]