Validation of methods for prediction of clinical output levels of active middle ear implants from measurements in human cadaveric ears.

ABSTRACT: Today, the standard method to predict output levels of active middle ear implants (AMEIs) before clinical data are available is stapes vibration measurement in human cadaveric ears, according to ASTM standard F2504-05. Although this procedure is well established, the validity of the predicted output levels has never been demonstrated clinically. Furthermore, this procedure requires a mobile and visually accessible stapes and an AMEI stimulating the ossicular chain. Thus, an alternative method is needed to quantify the output level of AMEIs in all other stimulation modes, e.g. reverse stimulation of the round window. Intracochlear pressure difference (ICPD) is a good candidate for such a method as it correlates with evoked potentials in animals and it is measurable in cadaveric ears. To val

SUBMITTER: Grossohmichen M 

PROVIDER: S-EPMC5696479 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature