PifC and Osa, Plasmid Weapons against Rival Conjugative Coupling Proteins.

ABSTRACT: Bacteria display a variety of mechanisms to control plasmid conjugation. Among them, fertility inhibition (FI) systems prevent conjugation of co-resident plasmids within donor cells. Analysis of the mechanisms of inhibition between conjugative plasmids could provide new alternatives to fight antibiotic resistance dissemination. In this work, inhibition of conjugation of broad host range IncW plasmids was analyzed in the presence of a set of co-resident plasmids. Strong FI systems against plasmid R388 conjugation were found in IncF/MOB_F12 as well as in IncI/MOB_P12 plasmids, represented by plasmids F and R64, respectively. In both cases, the responsible gene was pifC, known also to be involved in FI of IncP plasmids and Agrobacterium T-DNA transfer to plan

SUBMITTER: Getino M 

PROVIDER: S-EPMC5696584 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature