Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study.

ABSTRACT: Objective To describe the prevalence and clinical spectrum of microcephaly in South America for the period 2005-14, before the start of the Zika epidemic in 2015, as a baseline for future surveillance as the Zika epidemic spreads and as other infectious causes may emerge in future.Design Prevalence and case-control study.Data sources ECLAMC (Latin American Collaborative Study of Congenital Malformations) database derived from 107 hospitals in 10 South American countries, 2005 to 2014. Data on microcephaly cases, four non-malformed controls per case, and all hospital births (all births for hospital based prevalence, resident within municipality for population based prevalence). For 2010-14, head circumference data were available and compared with Intergrowth charts.R

SUBMITTER: Orioli IM 

PROVIDER: S-EPMC5696624 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature