Association of HIV Status With Local Immune Response to Anal Squamous Cell Carcinoma: Implications for Immunotherapy.

ABSTRACT:

Importance

The programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) pathway play an important immunosuppressive role in cancer and chronic viral infection, and have been effectively targeted in cancer therapy. Anal squamous cell carcinoma (SCC) is associated with both human papillomavirus and HIV infection. To date, patients with HIV have been excluded from most trials of immune checkpoint blocking agents, such as anti-PD-1 and anti-PD-L1, because it was assumed that their antitumor immunity was compromised compared with immunocompetent patients.

Objective

To compare the local tumor immune microenvironment (TME) in anal SCCs from HIV-positive and HIV-negative patients.

Design, setting, and participants

Anal SCC tumor specimens derived from the

SUBMITTER: Yanik EL 

PROVIDER: S-EPMC5696632 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature