Evolution of DWI lesions in cerebral amyloid angiopathy: Evidence for ischemia.

ABSTRACT:

Objective

To address the pathophysiologic nature of small diffusion-weighted imaging (DWI) lesions in patients with cerebral amyloid angiopathy (CAA) who underwent serial MRI. Specifically, we tested (1) whether DWI lesions occurred preferentially in individuals with prior DWI lesions, (2) the cross-sectional association with chronic cortical cerebral microinfarcts (CMIs), and (3) the evolution of DWI lesions over time.

Methods

Patients with probable CAA (n = 79) who underwent at least 2 MRI sessions were included. DWI lesions were assessed at each available time point. Lesion appearance and characteristics were assessed on available structural follow-up images. Presence and burden of other neuroimaging markers of small vessel disease (white matter hyperintensities, cerebral

SUBMITTER: van Veluw SJ 

PROVIDER: S-EPMC5696638 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature