Alzheimer disease brain atrophy subtypes are associated with cognition and rate of decline.

ABSTRACT:

Objective

To test the hypothesis that cortical and hippocampal volumes, measured in vivo from volumetric MRI (vMRI) scans, could be used to identify variant subtypes of Alzheimer disease (AD) and to prospectively predict the rate of clinical decline.

Methods

Amyloid-positive participants with AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI) 1 and ADNI2 with baseline MRI scans (n = 229) and 2-year clinical follow-up (n = 100) were included. AD subtypes (hippocampal sparing [HpSp_MRI], limbic predominant [LP_MRI], typical AD [tAD_MRI]) were defined according to an algorithm analogous to one recently proposed for tau neuropathology. Relationships between baseline hippocampal volume to cortical volume ratio (HV:CTV) and clinical variab

SUBMITTER: Risacher SL 

PROVIDER: S-EPMC5696639 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature