Cortical superficial siderosis multifocality in cerebral amyloid angiopathy: A prospective study.

ABSTRACT:

Objective

In order to explore the mechanisms of cortical superficial siderosis (cSS) multifocality and its clinical implications for recurrent intracerebral hemorrhage (ICH) risk in patients with cerebral amyloid angiopathy (CAA), we used a new rating method that we developed specifically to evaluate cSS extent at spatially separated foci.

Methods

Consecutive patients with CAA-related ICH according to Boston criteria from a single-center prospective cohort were analyzed. The new score that assesses cSS multifocality (total range 0-4) showed excellent interrater reliability (k = 0.87). The association of cSS with markers of CAA and acute ICH was investigated. Patients were followed prospectively for recurrent symptomatic ICH.

Results

The cohort included 313 patients wi

SUBMITTER: Charidimou A 

PROVIDER: S-EPMC5696643 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature