Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke.

ABSTRACT:

Objective

In patients with acute ischemic stroke, we aimed to investigate the relation between preexisting small vessel disease (SVD) and the amount of blood-brain barrier (BBB) leakage in ischemic and nonischemic area before IV thrombolysis.

Methods

We retrospectively accessed anonymous patient-level data from the Stroke Imaging Repository and the Virtual International Stroke Trials Archive resources and included patients treated with IV thrombolysis with pretreatment MRI. We rated SVD features using validated qualitative magnetic resonance (MR) scales. Leakage of BBB was assessed with postprocessing of perfusion-weighted images. We evaluated associations between SVD features (individually and summed in a global SVD score) and BBB leakage using linear regression analysis, a

SUBMITTER: Arba F 

PROVIDER: S-EPMC5696647 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature