Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides.

ABSTRACT: Micropeptides function as master regulators of calcium-dependent signaling in muscle. Sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA), the membrane pump that promotes muscle relaxation by taking up Ca²⁺ into the sarcoplasmic reticulum, is directly inhibited by three muscle-specific micropeptides: myoregulin (MLN), phospholamban (PLN), and sarcolipin (SLN). The widespread and essential function of SERCA across diverse cell types has raised questions as to how SERCA is regulated in cells that lack MLN, PLN, and SLN. We identified two transmembrane micropeptides, endoregulin (ELN) and another-regulin (ALN), that share key amino acids with their muscle-specific counterparts and function as direct inhibitors of SERCA pump activity. The distribution of transcripts encoding

SUBMITTER: Anderson DM 

PROVIDER: S-EPMC5696797 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature