Immunoproteomic analysis of the excretory-secretory products of Trichinella pseudospiralis adult worms and newborn larvae.

ABSTRACT:

Background

The nematode Trichinella pseudospiralis is an intracellular parasite of mammalian skeletal muscle cells and exists in a non-encapsulated form. Previous studies demonstrated that T. pseudospiralis could induce a lower host inflammatory response. Excretory-secretory (ES) proteins as the most important products of host-parasite interaction may play the main functional role in alleviating host inflammation. However, the ES products of T. pseudospiralis early stage are still unknown. The identification of the ES products of the early stage facilitates the understanding of the molecular mechanisms of the immunomodulation and may help finding early diagnostic markers.

Results

In this study, we used two-dimensional gel electrophoresis (2-DE)-based western blotting coupled

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5697079 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature