Reduced suppressive effect of β₂-adrenoceptor agonist on fibrocyte function in severe asthma.

ABSTRACT:

Background

Patients with severe asthma have increased airway remodelling and elevated numbers of circulating fibrocytes with enhanced myofibroblastic differentiation capacity, despite being treated with high doses of corticosteroids, and long acting β₂-adrenergic receptor (AR) agonists (LABAs). We determined the effect of β₂-AR agonists, alone or in combination with corticosteroids, on fibrocyte function.

Methods

Non-adherent non-T cells from peripheral blood mononuclear cells isolated from healthy subjects and patients with non-severe or severe asthma were treated with the β₂-AR agonist, salmeterol, in the presence or absence of the corticosteroid dexamethasone. The number of fibrocytes (collagen I⁺/CD45⁺ cells) and dif

SUBMITTER: Lo CY 

PROVIDER: S-EPMC5697384 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature