The role of stress-regulation genes in moderating the association of stress and daily-life psychotic experiences.

ABSTRACT:

Objective

The interaction of single nucleotide polymorphisms with both distal and proximal environmental factors across the extended psychosis phenotype is understudied. This study examined (i) the interaction of relevant SNPs with both early-life adversity and proximal (momentary) stress on psychotic experiences (PEs) in an extended psychosis sample; and (ii) differences between early-psychosis and non-clinical groups for these interactions.

Methods

Two hundred and forty-two non-clinical and 96 early-psychosis participants were prompted randomly eight times daily for 1 week to complete assessments of current experiences, including PEs and stress. Participants also reported on childhood trauma and were genotyped for 10 SNPs on COMT, RGS4, BDNF, FKBP5, and OXTR genes.

Resu

SUBMITTER: Cristobal-Narvaez P 

PROVIDER: S-EPMC5697578 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature