Phosphodiester content measured in human liver by in vivo ³¹ P MR spectroscopy at 7 tesla.

ABSTRACT:

Purpose

Phosphorus (³¹ P) metabolites are emerging liver disease biomarkers. Of particular interest are phosphomonoester and phosphodiester (PDE) "peaks" that comprise multiple overlapping resonances in ³¹ P spectra. This study investigates the effect of improved spectral resolution at 7 Tesla (T) on quantifying hepatic metabolites in cirrhosis.

Methods

Five volunteers were scanned to determine metabolite T₁ s. Ten volunteers and 11 patients with liver cirrhosis were scanned at 7T. Liver spectra were acquired in 28 min using a 16-channel ³¹ P array and 3D chemical shift imaging. Concentrations were calculated using γ-adenosine-triphosphate (γ-ATP) = 2.65 mmol/L wet tissue.

Results

T₁ means ± standard deviations: p

SUBMITTER: Purvis LAB 

PROVIDER: S-EPMC5697655 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature