Human amnion favours tissue repair by inducing the M1-to-M2 switch and enhancing M2 macrophage features.

ABSTRACT: Human amniotic mesenchymal cells (hAMTCs) possess interesting immunomodulatory properties, making them attractive candidates for regenerative medicine applications. Recent in vivo reports argue in favour of an important role for macrophages as targets of hAMTC-mediated suppression of inflammation and the enhancement of tissue repair. However, a comprehensive study of the effects of hAMTCs and their conditioned medium (CM) on human macrophage differentiation and function is unavailable. In the present study we found that hAMTCs and CM induce the differentiation of myeloid cells (U937 and monocytes) towards macrophages. We then investigated their effects on monocytes differentiated toward pro-inflammatory M1 and anti-inflammatory M2 macrophages. Monocytes treated under M1 conditions in the p

SUBMITTER: Magatti M 

PROVIDER: S-EPMC5697700 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature