Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study.

ABSTRACT:

Aims/hypothesis

Respiratory infections and onset of islet autoimmunity are reported to correlate positively in two small prospective studies. The Environmental Determinants of Diabetes in the Young (TEDDY) study is the largest prospective international cohort study on the environmental determinants of type 1 diabetes that regularly monitors both clinical infections and islet autoantibodies. The aim was to confirm the influence of reported respiratory infections and to further characterise the temporal relationship with autoantibody seroconversion.

Methods

During the years 2004-2009, 8676 newborn babies with HLA genotypes conferring an increased risk of type 1 diabetes were enrolled at 3 months of age to participate in a 15 year follow-up. In the present study, the associatio

SUBMITTER: Lonnrot M 

PROVIDER: S-EPMC5697762 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature