Epithelial periostin expression is correlated with poor survival in patients with invasive breast carcinoma.

ABSTRACT: Invasion and metastasis are direct causes of mortality in patients with breast cancer and require reciprocal interactions between cancer cells and the extracellular matrix (ECM). Periostin, a fasciclin-containing adhesive ECM glycoprotein, is frequently overexpressed in various types of human cancer, and its overexpression in cancer-associated stroma and/or cancer cells is usually associated with poor clinical outcomes. However, the expression of periostin in the successive steps of breast tumorigenesis and its association with outcome variables have not been well established in breast carcinoma. The present study aimed to assess the role of periostin alteration in breast tumorigenesis and evaluate the putative prognostic value of periostin as a function of its compartmentalization. Immuno

SUBMITTER: Kim GE 

PROVIDER: S-EPMC5697858 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature