Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development.

ABSTRACT: The coronary vasculature is an essential vessel network providing the blood supply to the heart. Disruptions in coronary blood flow contribute to cardiac disease, a major cause of premature death worldwide. The generation of treatments for cardiovascular disease will be aided by a deeper understanding of the developmental processes that underpin coronary vessel formation. From an ENU mutagenesis screen, we have isolated a mouse mutant displaying embryonic hydrocephalus and cardiac defects (EHC). Positional cloning and candidate gene analysis revealed that the EHC phenotype results from a point mutation in a splice donor site of the Myh10 gene, which encodes NMHC IIB. Complementation testing confirmed that the Myh10 mutation causes the EHC phenotype. Characterisation of the EHC cardiac defe

SUBMITTER: Ridge LA 

PROVIDER: S-EPMC5697871 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature