A modeling study of budding yeast colony formation and its relationship to budding pattern and aging.

ABSTRACT: Budding yeast, which undergoes polarized growth during budding and mating, has been a useful model system to study cell polarization. Bud sites are selected differently in haploid and diploid yeast cells: haploid cells bud in an axial manner, while diploid cells bud in a bipolar manner. While previous studies have been focused on the molecular details of the bud site selection and polarity establishment, not much is known about how different budding patterns give rise to different functions at the population level. In this paper, we develop a two-dimensional agent-based model to study budding yeast colonies with cell-type specific biological processes, such as budding, mating, mating type switch, consumption of nutrients, and cell death. The model demonstrates that the axial budding patter

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5697893 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature