Task Demands Predict a Dynamic Switch in the Content of Awake Hippocampal Replay.

ABSTRACT: Reactivation of hippocampal place cell sequences during behavioral immobility and rest has been linked with both memory consolidation and navigational planning. Yet it remains to be investigated whether these functions are temporally segregated, occurring during different behavioral states. During a self-paced spatial task, awake hippocampal replay occurring either immediately before movement toward a reward location or just after arrival at a reward location preferentially involved cells consistent with the current trajectory. In contrast, during periods of extended immobility, no such biases were evident. Notably, the occurrence of task-focused reactivations predicted the accuracy of subsequent spatial decisions. Additionally, during immobility, but not periods preceding or succeeding mo

SUBMITTER: Olafsdottir HF 

PROVIDER: S-EPMC5697915 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature