Blocking TGF-β and β-Catenin Epithelial Crosstalk Exacerbates CKD.

ABSTRACT: The TGF-β and Wnt/β-catenin pathways have important roles in modulating CKD, but how these growth factors affect the epithelial response to CKD is not well studied. TGF-β has strong profibrotic effects, but this pleiotropic factor has many different cellular effects depending on the target cell type. To investigate how TGF-β signaling in the proximal tubule, a key target and mediator of CKD, alters the response to CKD, we injured mice lacking the TGF-β type 2 receptor specifically in this epithelial segment. Compared with littermate controls, mice lacking the proximal tubular TGF-β receptor had significantly increased tubular injury and tubulointerstitial fibrosis in two different models of CKD. RNA sequencing indicated that deleting the TGF-β</

SUBMITTER: Nlandu-Khodo S 

PROVIDER: S-EPMC5698068 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature