Spontaneous food allergy in Was^-/- mice occurs independent of FcεRI-mediated mast cell activation.

ABSTRACT:

Background

Food allergies are a growing health problem, and the development of therapies that prevent disease onset is limited by the lack of adjuvant-free experimental animal models. We compared allergic sensitization in patients with food allergy or Wiskott-Aldrich syndrome (WAS) and defined whether spontaneous disease in Was^-/- mice recapitulates the pathology of a conventional disease model and/or human food allergy.

Methods

Comparative ImmunoCAP ISAC microarray was performed in patients with food allergy or WAS. Spontaneous food allergy in Was^-/- mice was compared to an adjuvant-based model in wild-type mice (WT-OVA/alum). Intestinal and systemic anaphylaxis was assessed, and the role of the high-affinity IgE Fc receptor (FcεRI) in allergic sensiti

SUBMITTER: Lexmond WS 

PROVIDER: S-EPMC5698178 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature