Ontology highlight
ABSTRACT:
SUBMITTER: Austin S
PROVIDER: S-EPMC5698270 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Austin Shane S Tavakoli Mojtaba M Pfeiffer Christina C Seifert Julia J Mattarei Andrea A De Stefani Diego D Zoratti Mario M Nowikovsky Karin K
Frontiers in physiology 20171117
Ca<sup>2+</sup> transport across the inner membrane of mitochondria (IMM) is of major importance for their functions in bioenergetics, cell death and signaling. It is therefore tightly regulated. It has been recently proposed that LETM1—an IMM protein with a crucial role in mitochondrial K<sup>+</sup>/H<sup>+</sup> exchange and volume homeostasis—also acts as a Ca<sup>2+</sup>/H<sup>+</sup> exchanger. Here we show for the first time that lowering LETM1 gene expression by shRNA hampers mitochondr ...[more]