Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs.

ABSTRACT: Canine Visceral Leishmaniasis (CVL) is caused by Leishmania infantum, which in the New World is transmitted by Lutzomyia longipalpis. While prospective clinical and immunological assessments of dogs experimentally challenged with L. infantum have been previously reported over a relatively short follow-up period, the long-term characterization of infected animals has not been performed to date. We evaluated dogs in a subclinical state for six years following experimental infection with L. infantum and Lu. longipalpis saliva, via an intradermal route, to characterize clinical, parasitological and immunological parameters arising from L. infantum experimental infection. We also assess these parameters in a group of naturally infected animals. The immune profiles of the experimentally and natu

SUBMITTER: Abbehusen MMC 

PROVIDER: S-EPMC5698407 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature