MiRDDCR: a miRNA-based method to comprehensively infer drug-disease causal relationships.

ABSTRACT: Revealing the cause-and-effect mechanism behind drug-disease relationships remains a challenging task. Recent studies suggested that drugs can target microRNAs (miRNAs) and alter their expression levels. In the meanwhile, the inappropriate expression of miRNAs will lead to various diseases. Therefore, targeting specific miRNAs by small-molecule drugs to modulate their activities provides a promising approach to human disease treatment. However, few studies attempt to discover drug-disease causal relationships through the molecular level of miRNAs. Here, we developed a miRNA-based inference method miRDDCR to comprehensively predict drug-disease causal relationships. We first constructed a three-layer drug-miRNA-disease heterogeneous network by combining similarity measurements, existing dru

SUBMITTER: Chen H 

PROVIDER: S-EPMC5698443 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature