Suboptimal cotrimoxazole prophylactic concentrations in HIV-infected children according to the WHO guidelines.

ABSTRACT:

Aims

A clinical study was conduct in HIV-infected children to evaluate the prophylactic doses of cotrimoxazole [sulfamethoxazole (SMX) and trimethoprim (TMP)] advised by the WHO.

Methods

Children received lopinavir-based antiretroviral therapy with cotrimoxazole prophylaxis (200 mg of SMX/40 mg of TMP once daily). A nonlinear mixed effects modelling approach was used to analyse plasma concentrations. Factors that could impact the pharmacokinetic profile were investigated. The model was subsequently used to simulate individual exposure and evaluate different administration schemes.

Results

The cohort comprised 136 children [average age: 1.9 years (range: [0.7-4]), average weight: 9.5 kg (range: [6-16.3])]. A dose per kg was justified by the significant influence of imp

SUBMITTER: Pressiat C 

PROVIDER: S-EPMC5698578 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature