Decremental responses in patients with motor neuron disease.

ABSTRACT:

Objective

Involvement of the neuromuscular junction (NMJ) in amyotrophic lateral sclerosis (ALS) has been reported and is increasingly recognized as an important pathophysiological aspect. The relationship between decrement and clinical measures for possible application as a biomarker has not been comprehensively explored.

Methods

We performed routine repetitive nerve stimulation (RNS) of three nerves on patients with ALS. We captured measures of muscle strength, grip strength, fatigability, and calculated slow vital capacity (SVC) rates of change assessing for associations.

Results

In 42 subjects, 210 muscles were studied. Negative correlation was found between the percentage of decrement and compound muscle action potential (CMAP) amplitude. Approximately half of th

SUBMITTER: Alanazy MH 

PROVIDER: S-EPMC5698864 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature