Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use.

ABSTRACT:

Objective

COMT rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample.

Methods

One hundred and sixty-nine subjects with psychosis were recruited. AoP, defined as age of DSM-IV diagnosis was established using the Structured Clinical Interview for DSM-IV. Cannabis use data were collected using a self-report computerized questionnaire. DNA was extracted from saliva and genotyping of the COMT Val158Met polymorphism was done by SNaPshot and TaqMan assays. Kaplan-Meier analysis results are reported.

Results

In those who had used cannabis before 20 years of age, rs4680 had a trend level eff

SUBMITTER: Lodhi RJ 

PROVIDER: S-EPMC5698868 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature