NS-Pten knockout mice show sex- and age-specific differences in ultrasonic vocalizations.

ABSTRACT:

Objective

The goal of this study was to identify changes in quantitative and qualitative aspects of neonatal ultrasonic vocalizations USVs in neuron-subset specific (NS-Pten) knockout males and females when compared with wild-type male and female mice.

Background

One signaling cascade that plays a crucial role in the development of an autistic-like phenotype is the PI3K/Akt/mTOR pathway. Mouse models that illustrate this connection include Fmr1, Tsc1, and NS-Pten-deficient mice. While numerous studies have investigated ultrasonic vocalizations in Fmr1 knockout and Tsc1 heterogenous mice, none have investigated USVs in NS-Pten knockout mice using a full spectrum recording system.

Methods

We recorded ultrasonic vocalizati

SUBMITTER: Binder MS 

PROVIDER: S-EPMC5698873 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature