Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism.

ABSTRACT: Decades of work in experimental animals has established the importance of visual experience during critical periods for the development of normal sensory-evoked responses in the visual cortex. However, much less is known concerning the impact of early visual experience on the systems-level organization of spontaneous activity. Human resting-state fMRI has revealed that infraslow fluctuations in spontaneous activity are organized into stereotyped spatiotemporal patterns across the entire brain. Furthermore, the organization of spontaneous infraslow activity (ISA) is plastic in that it can be modulated by learning and experience, suggesting heightened sensitivity to change during critical periods. Here we used wide-field optical intrinsic signal imaging in mice to examine whole-cortex sponta

SUBMITTER: Kraft AW 

PROVIDER: S-EPMC5699067 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature