Elevated Aspergillus-specific antibody levels among HIV infected Ugandans with pulmonary tuberculosis.

ABSTRACT:

Background

The incidence of tuberculosis (TB) is high among human immunodeficiency virus (HIV) infected Ugandans. Recent evidence suggests that Chronic Pulmonary Aspergillosis and Aspergillus sensitisation might be responsible for significant mortality in patients treated for tuberculosis in Uganda.

Methods

We retrieved and tested paired serum aliquots for 101 HIV-TB co-infected patients at the beginning and week 24 of TB treatment. We tested samples for Aspergillus-specific immunoglobulin G (IgG) and immunoglobulin E (IgE) using ImmunoCAP®; and Aspergillus-specific IgG and total serum IgE using Immulite® immunoassays. We compared antibody levels between baseline and week 24, relating them to selected baseline characteristics.

Results

10% of the patients had elevated

SUBMITTER: Kwizera R 

PROVIDER: S-EPMC5699185 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature