Photon-counting CT for simultaneous imaging of multiple contrast agents in the abdomen: An in vivo study.

ABSTRACT:

Purpose

To demonstrate the feasibility of spectral imaging using photon-counting detector (PCD) x-ray computed tomography (CT) for simultaneous material decomposition of three contrast agents in vivo in a large animal model.

Methods

This Institutional Animal Care and Use Committee-approved study used a canine model. Bismuth subsalicylate was administered orally 24-72 h before imaging. PCD CT was performed during intravenous administration of 40-60 ml gadoterate meglumine; 3.5 min later, iopamidol 370 was injected intravenously. Renal PCD CT images were acquired every 2 s for 5-6 min to capture the wash-in and wash-out kinetics of the contrast agents. Least mean squares linear material decomposition was used to calculate the concentrations of contrast agents in the aorta, ren

SUBMITTER: Symons R 

PROVIDER: S-EPMC5699215 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature