Protein-protein interactions leave evolutionary footprints: High molecular coevolution at the core of interfaces.

ABSTRACT: Protein-protein interactions are essential to all aspects of life. Specific interactions result from evolutionary pressure at the interacting interfaces of partner proteins. However, evolutionary pressure is not homogeneous within the interface: for instance, each residue does not contribute equally to the binding energy of the complex. To understand functional differences between residues within the interface, we analyzed their properties in the core and rim regions. Here, we characterized protein interfaces with two evolutionary measures, conservation and coevolution, using a comprehensive dataset of 896 protein complexes. These scores can detect different selection pressures at a given position in a multiple sequence alignment. We also analyzed how the number of interactions in which a

SUBMITTER: Teppa E 

PROVIDER: S-EPMC5699499 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature