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Efficient route to pre-organized and linear polyaminopolycarboxylates: Cy-TTHA, Cy-DTPA and mono/di- reactive, tert-butyl protected TTHA/Cy-TTHA.

ABSTRACT: Pre-organized polyaminopolycarboxylate chelators Cy-TTHA and Cy-DTPA were synthesized via modular five-step syntheses from commercially available starting materials in ~ 62% and 47% overall yields, respectively. Furthermore, strategies are reported for the efficient preparation of mono- and di-reactive, tert-butyl-protected TTHA/Cy-TTHA to selectively functionalize central chelators' carboxylic acids.

SUBMITTER: Mohamadi A

PROVIDER: S-EPMC5699510 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Efficient route to pre-organized and linear polyaminopolycarboxylates: Cy-TTHA, Cy-DTPA and mono/di- reactive, <i>tert</i>-butyl protected TTHA/Cy-TTHA.

Mohamadi Ali A Miller Lawrence W LW

Tetrahedron letters 20170220 15

Pre-organized polyaminopolycarboxylate chelators Cy-TTHA and Cy-DTPA were synthesized via modular five-step syntheses from commercially available starting materials in ~ 62% and 47% overall yields, respectively. Furthermore, strategies are reported for the efficient preparation of mono- and di-reactive, <i>tert</i>-butyl-protected TTHA/Cy-TTHA to selectively functionalize central chelators' carboxylic acids. ...[more]

PMID: 29176914

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