Frequency of five disease-causing genetic mutations in a large mixed-breed dog population (2011-2012).

ABSTRACT:

Background

A large and growing number of inherited genetic disease mutations are now known in the dog. Frequencies of these mutations are typically examined within the breed of discovery, possibly in related breeds, but nearly always in purebred dogs. No report to date has examined the frequencies of specific genetic disease mutations in a large population of mixed-breed dogs. Further, veterinarians and dog owners typically dismiss inherited/genetic diseases as possibilities for health problems in mixed-breed dogs, assuming hybrid vigor will guarantee that single-gene disease mutations are not a cause for concern. Therefore, the objective of this study was to screen a large mixed-breed canine population for the presence of mutant alleles associated with five autosomal recessive dis

SUBMITTER: Zierath S 

PROVIDER: S-EPMC5699815 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature