Unpredictable chronic mild stress differentially impairs social and contextual discrimination learning in two inbred mouse strains.

ABSTRACT: Alterations in the social and cognitive domain are considered important indicators for increased disability in many stress-related disorders. Similar impairments have been observed in rodents chronically exposed to stress, mimicking potential endophenotypes of stress-related psychopathologies such as major depression disorder (MDD), anxiety, conduct disorder, and posttraumatic stress disorder (PTSD). Data from numerous studies suggest that deficient plasticity mechanisms in hippocampus (HC) and prefrontal cortex (PFC) might underlie these social and cognitive deficits. Specifically, stress-induced deficiencies in neural plasticity have been associated with a hypodopaminergic state and reduced neural plasticity persistence. Here we assessed the effects of unpredictable chronic mild stress (

SUBMITTER: van Boxelaere M 

PROVIDER: S-EPMC5699833 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature