Different response to hypoxia of adipose-derived multipotent cells from obese subjects with and without metabolic syndrome.

ABSTRACT:

Background/objectives

Multiple studies suggest that hypoxia, together with inflammation, could be one of the phenomena involved in the onset and progression of obesity-related insulin resistance. In addition, dysfunction of adipose tissue in obese subjects with metabolic syndrome is associated with decreased angiogenesis. However, some subjects with a high body mass index do not develop metabolic abnormalities associated with obesity. The aim of the current study was to examine the neovascular properties of visceral adipose tissue-derived multipotent mesenchymal cells subjected to hypoxia (hypox-visASCs) from normal-weight subjects (Nw) and obese patients with metabolic syndrome (MS) and without metabolic syndrome (NonMS).

Methods

This was a 2-year study to enroll subjects w

SUBMITTER: Oliva-Olivera W 

PROVIDER: S-EPMC5699836 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature