Regulatory network structure determines patterns of intermolecular epistasis.

ABSTRACT: Most phenotypes are determined by molecular systems composed of specifically interacting molecules. However, unlike for individual components, little is known about the distributions of mutational effects of molecular systems as a whole. We ask how the distribution of mutational effects of a transcriptional regulatory system differs from the distributions of its components, by first independently, and then simultaneously, mutating a transcription factor and the associated promoter it represses. We find that the system distribution exhibits increased phenotypic variation compared to individual component distributions - an effect arising from intermolecular epistasis between the transcription factor and its DNA-binding site. In large part, this epistasis can be qualitatively attributed to th

SUBMITTER: Lagator M 

PROVIDER: S-EPMC5699867 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature