A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss.

ABSTRACT: OBJECTIVE:Previous studies have reported that polyphenol-rich extracts from various sources can prevent obesity and associated gastro-hepatic and metabolic disorders in diet-induced obese (DIO) mice. However, whether such extracts can reverse obesity-linked metabolic alterations remains unknown. In the present study, we aimed to investigate the potential of a polyphenol-rich extract from cranberry (CE) to reverse obesity and associated metabolic disorders in DIO-mice. METHODS:Mice were pre-fed either a Chow or a High Fat-High Sucrose (HFHS) diet for 13 weeks to induce obesity and then treated either with CE (200 mg/kg, Chow + CE, HFHS + CE) or vehicle (Chow, HFHS) for 8 additional weeks. RESULTS:CE did not reverse weight gain or fat mass accretion in Chow- or HFHS-fed mice. However, HFHS +

SUBMITTER: Anhe FF 

PROVIDER: S-EPMC5699918 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature