Arctic ground squirrel resist peroxynitrite-mediated cell death in response to oxygen glucose deprivation.

ABSTRACT: Cerebral ischemia-reperfusion (I/R) injury initiates a cascade of events, generating nitric oxide (NO) and superoxide(O₂^•-) to form peroxynitrite (ONOO^-), a potent oxidant. Arctic ground squirrels (AGS; Urocitellus parryii) show high tolerance to I/R injury. However, the underlying mechanism remains elusive. We hypothesize that tolerance to I/R modeled in an acute hippocampal slice preparation in AGS is modulated by reduced oxidative and nitrative stress. Hippocampal slices (400µm) from rat and AGS were subjected to oxygen glucose deprivation (OGD) using a novel microperfusion technique. Slices were exposed to NO, O₂^.- donors with and without OGD; pretreatment with inhibitors of NO, O₂^.- and ONOO^- follo

SUBMITTER: Bhowmick S 

PROVIDER: S-EPMC5699938 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature