Factors Influencing Successful Lumbar Puncture in Alzheimer Research.

ABSTRACT:

Objective

Lumbar puncture (LP) is increasingly common in Alzheimer disease research; however, agreement to undergo LP varies. We sought to determine factors influencing LP consent at Alzheimer's Disease Centers (ADCs) in the United States.

Methods

A 3-part survey was distributed to each ADC: (1) ADC LP Experience; (2) LP Requestor Experience; and (3) Patient LP Experience (both Initial and Follow-up). In all, 64 LP Requestor, 579 Patient/Initial, and 404 Patient/Follow-up surveys were collected. Logistic regression analyses with generalized estimating equations were used to assess factors associated with LP agreement and post-LP complications.

Results

Asians and those viewing LP negatively were less likely to agree to LP. Three hundred fifty-two participants had an LP

SUBMITTER: Moulder KL 

PROVIDER: S-EPMC5699954 | biostudies-literature | 2017 Oct-Dec

REPOSITORIES: biostudies-literature