Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease.

ABSTRACT:

Objective

Patients with IBD display substantial heterogeneity in clinical characteristics. We hypothesise that individual differences in the complex interaction of the host genome and the gut microbiota can explain the onset and the heterogeneous presentation of IBD. Therefore, we performed a case-control analysis of the gut microbiota, the host genome and the clinical phenotypes of IBD.

Design

Stool samples, peripheral blood and extensive phenotype data were collected from 313 patients with IBD and 582 truly healthy controls, selected from a population cohort. The gut microbiota composition was assessed by tag-sequencing the 16S rRNA gene. All participants were genotyped. We composed genetic risk scores from 11 functional genetic variants proven to be associated with IBD in

SUBMITTER: Imhann F 

PROVIDER: S-EPMC5699972 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature