Natural selection between day 3 and day 5/6 PGD embryos in couples with reciprocal or Robertsonian translocations.

ABSTRACT:

Purpose

For translocation carriers, preimplantation genetic diagnosis (PGD) provides the opportunity to distinguish between normal/balanced and unbalanced embryos prior to implantation and, as such, increases the likelihood of a successful ongoing pregnancy. The data presented here compares autosomal reciprocal and Robertsonian translocation segregation patterns in day 3 versus day 5/6 IVF-PGD embryos to determine if there is a difference in the chromosome segregation patterns observed at these developmental time points.

Methods

A retrospective analysis on PGD translocation carriers at Monash IVF was performed. Segregation patterns were compared between day 3 and day 5/6 embryos to ascertain whether selection against malsegregants exists.

Results

For reciprocal transl

SUBMITTER: Beyer CE 

PROVIDER: S-EPMC5699989 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature