Characterization of the early molecular changes in the glomeruli of Cd151 ^-/- mice highlights induction of mindin and MMP-10.

ABSTRACT: In humans and FVB/N mice, loss of functional tetraspanin CD151 is associated with glomerular disease characterised by early onset proteinuria and ultrastructural thickening and splitting of the glomerular basement membrane (GBM). To gain insight into the molecular mechanisms associated with disease development, we characterised the glomerular gene expression profile at an early stage of disease progression in FVB/N Cd151 ^-/- mice compared to Cd151 ^+/+ controls. This study identified 72 up-regulated and 183 down-regulated genes in FVB/N Cd151 ^-/- compared to Cd151 ^+/+ glomeruli (p < 0.05). Further analysis highlighted induction of the matrix metalloprotease MMP-10 and the extracellular matrix protein mindin (encoded by Spon2) in the diseased FVB/N

SUBMITTER: Naudin C 

PROVIDER: S-EPMC5700190 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature