Disruption of Ankyrin B and Caveolin-1 Interaction Sites Alters Na⁺,K⁺-ATPase Membrane Diffusion.

ABSTRACT: The Na⁺,K⁺-ATPase is a plasma membrane ion transporter of high physiological importance for ion homeostasis and cellular excitability in electrically active tissues. Mutations in the genes coding for Na⁺,K⁺-ATPase α-subunit isoforms lead to severe human pathologies including Familial Hemiplegic Migraine type 2, Alternating Hemiplegia of Childhood, Rapid-onset Dystonia Parkinsonism, or epilepsy. Many of the reported mutations lead to change- or loss-of-function effects, whereas others do not alter the functional properties, but lead to, e.g., reduced protein stability, reduced protein expression, or defective plasma membrane targeting. Na⁺,K⁺-ATPase frequently assembles with other membrane transporters or cellular matrix prot

SUBMITTER: Junghans C 

PROVIDER: S-EPMC5700257 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature